Iodine → HCID 178481731, compound

HRID 2205834Notes

Reaction equation

HRID 2205834 reaction equation
C1([I:7](OC(=O)C(F)(F)F)OC(=O)C(F)(F)F)C=CC=CC=1.[CH3:22][N:23]1[C:27]2[N:28]=[N:29][CH:30]=[C:31]([OH:32])[C:26]=2[C:25]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[N:24]1.II.N1C=CC=CC=1>C(Cl)Cl>[I:7][C:30]1[N:29]=[N:28][C:27]2[N:23]([CH3:22])[N:24]=[C:25]([C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)[C:26]=2[C:31]=1[OH:32]

Participants

6

Reactant 4

HCID 807IodineHCID 1049PyridineHCID 102317Bis(trifluoroacetoxy)iodobenzeneHCID 178481732HCID 178481732, compound

Product 1

HCID 178481731HCID 178481731, compoundYield 105.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Phenyl[bis(2,2,2-trifluoroacetoxy)]-λ3-iodane (190 mg, 0.43 mmol) was added to a suspension of 1-methyl-3-phenyl-pyrazolo[3,4-c]pyridazin-4-ol (166 mg, 0.73 mmol) in CH2Cl2 (3.7 mL), followed by the addition of iodine (111 mg, 0.43 mmol) and pyridine (71 μL). The reaction mixture was stirred at room temperature for 16 h, then filtered. The collected solid was washed with CH2Cl2 and dried, to yield the title compound (160 mg).

Workup

  1. filtrationfiltered
  2. washThe collected solid was washed with CH2Cl2
  3. customdried

Sources & evidence

ORD record
ord-d6c59b5fbe2d467fb7aeb83a3fe1a572
Source dataset
uspto-grants-2016_06
Patent number
US09371332B2

Reaction notes

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