1-Pyrrolidineethanol → HCID 90111298, compound

HRID 2205849Notes

Reaction equation

[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[NH:14][N:15]=[C:16]([CH3:17])[C:3]=12.[N:18]1([CH2:23][CH2:24]O)[CH2:22][CH2:21][CH2:20][CH2:19]1>>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[N:14]([CH2:24][CH2:23][N:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)[N:15]=[C:16]([CH3:17])[C:3]=12

Participants

Reactant 2

HCID 762881-Pyrrolidineethanol

HCID 86717276CID 86717276

Product 1

HCID 90111298HCID 90111298, compound

Procedure

Compound XIIId was synthesized from 4-chloro-3-methyl-5-phenyl-1H-pyrazolo[3,4-c]pyridazine and 2-(pyrrolidin-1-yl)ethanol following the general procedure for the Mitsunobu reaction described in Example 20.

Workup

customfor the Mitsunobu reaction

Sources & evidence

ORD record: ord-dd611e1e7714483a9edb1e2a6e51f0d6
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09371332B2

Reaction notes

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