1-(2-Hydroxyethyl)-1H-pyrazole → HCID 90112314, compound

HRID 2205850Notes

Reaction equation

HRID 2205850 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[NH:14][N:15]=[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:3]=12.[N:23]1([CH2:28][CH2:29]O)[CH:27]=[CH:26][CH:25]=[N:24]1>>[Cl:1][C:2]1[C:7]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[N:6][N:5]=[C:4]2[N:14]([CH2:29][CH2:28][N:23]3[CH:27]=[CH:26][CH:25]=[N:24]3)[N:15]=[C:16]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[C:3]=12

Participants

3

Reactant 2

HCID 2370311-(2-Hydroxyethyl)-1H-pyrazoleHCID 86697018CID 86697018

Product 1

HCID 90112314HCID 90112314, compound

Procedure

Compound XIVa was synthesized from 4-chloro-3,5-diphenyl-1H-pyrazolo[3,4-c]pyridazine and 2-(1H-pyrazol-1-yl)ethanol following the general procedure for the Mitsunobu reaction described in Example 20.

Workup

  1. customfor the Mitsunobu reaction

Sources & evidence

ORD record
ord-20cd814e0b4f4991a84cf787ce758947
Source dataset
uspto-grants-2016_06
Patent number
US09371332B2

Reaction notes

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