4-(1H-pyrazol-1-ylmethyl)aniline → HCID 86706287, compound

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Reaction Steps

The title compound was prepared from tert-butyl 6-bromo-2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate (10) (70 mg, 0.15 mmol) and 4-((1H-pyrazol-1-yl)methyl)aniline (31.3 mg, 0.181 mmol, 1.2 eq), using the method described in Preparation 35 and using silica gel column chromatography eluting with EtOAc:hexane:triethylamine 10:10:1 (12 mg, 14.3%). 1H-NMR (500 MHz, CDCl3) 1.49 (s, 9H), 1.69 (s, 9H), 5.2 (s, 2H), 6.32 (s, 1H), 6.58 (s, 1H), 6.66 (d, J=8.3 Hz, 2H), 7 (d, J=8.5 Hz, 1H), 7.06 (d, J=8.3 Hz, 2H), 7.23 (d, J=8.5 Hz, 1H), 7.33 (m, 1H), 7.62 (s, 1H), 7.82 (s, 1H), 8.21 (s, 1H), 8.45 (s, 1H).

Provenance & Evidence