4-(2-Morpholinoethoxy)aniline → HCID 86706288, compound

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Reaction Steps

The title compound was prepared from tert-butyl 6-bromo-2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate (10) (100 mg, 0.216 mmol) and 4-(2-morpholinoethoxy)aniline (58 mg, 0.26 mmol, 1.2 eq) using the method described in Preparation 35 and using silica gel column chromatography eluting with EtOAc:hexane:triethylamine 10:10:1 (20 mg, 15%). 1H-NMR (500 MHz, CDCl3) 1.45 (s, 9H), 1.67 (s, 9H), 2.58 (m, 4H), 2.8 (t, J=5.8 Hz, 2H), 3.73 (m, 4H), 4.11 (t, J=5.8 Hz, 2H), 6.54 (s, 1H), 6.6 (s, 1H), 6.91 (d, J=8.9 Hz, 2H), 7.27 (d, J=8.9 Hz, 2H), 7.37 (s, 1H), 7.8 (s, 1H), 8.19 (s, 1H), 8.39 (s, 1H).

Provenance & Evidence