1-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-one → HCID 86706300, compound

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Reaction Steps

The title compound was prepared in 27% yield from compound (17) and 4-(4-acetylpiperazin-1-yl)aniline using the method described for compound (49). 1H-NMR (500 MHz, CDCl3) 1.47 (s, 9H), 1.69 (s, 9H), 2.17 (s, 3H), 3.13 (t, J=5.0 Hz, 2H), 3.15 (t, J=5.3 Hz, 2H), 3.65 (t, J=5.8 Hz, 2H), 3.81 (t, J=5.2 Hz, 2H), 6.45 (br s, 1H), 6.56 (d, J=0.6 Hz, 1H), 6.96 (d, J=8.9 Hz, 2H), 7.29 (d, J=8.9 Hz, 2H), 7.42 (s, 1H), 7.81 (d, J=0.6 Hz, 1H), 8.20 (d, J=0.4 Hz, 1H), 8.41 (d, J=0.8 Hz, 1H).

Provenance & Evidence