1-(3-Methoxy-4-nitrophenyl)-N,N-dimethylmethanamine → 4-((Dimethylamino)methyl)-2-methoxyaniline

Participants

Reaction Steps

10% Pd on carbon (12 mg, 0.866 mmol) was added to a solution of 1-(3-methoxy-4-nitrophenyl)-N,N-dimethylmethanamine (Preparation 109, 160 mg, 0.76 mmol) in EtOH (3 mL). The reaction mixture was degassed and then stirred for 1 hour at room temperature under an atmosphere of hydrogen before being filtered on a pad of Celite and concentrated under reduced pressure to afford the title compound (0.135 g, 98%).

Provenance & Evidence