HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-Benzyl-2-methoxypyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Iodobenzene | HCID 11575 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | 7-methoxy-3-phenyl-1H-pyrazolo[3,4-c]pyridine | HCID 117988046 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-Benzyl-2-methoxypyridin-3-amine | HCID 117987838 | 69.8% |
Reaction Steps
A solution of 7-methoxy-3-phenyl-1H-pyrazolo[3,4-c]pyridine (113 mg), iodobenzene (1.02 g), L-proline (23.0 mg), potassium carbonate (346 mg) and copper(I) iodide (19.1 mg) in DMSO (10 mL) was stirred under nitrogen atmosphere at 180° C. for 1 hr. The reaction mixture was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (75 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371320B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-88632d28cfc94911a370e3314caacef4 |
| Source note | uspto-grants-2016_06 |