HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 7-methoxy-3-phenyl-1-(3-thienyl)-1H-pyrazolo[3,4-c]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Iodothiophene | HCID 66332 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | 7-methoxy-3-phenyl-1H-pyrazolo[3,4-c]pyridine | HCID 117988046 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 7-methoxy-3-phenyl-1-(3-thienyl)-1H-pyrazolo[3,4-c]pyridine | HCID 117987951 | 9.3% |
Reaction Steps
A solution of 7-methoxy-3-phenyl-1H-pyrazolo[3,4-c]pyridine (225 mg) obtained in Step C of Example 10, 3-iodothiophene (1.05 g), L-proline (46.1 mg), potassium carbonate (691 mg) and copper(I) iodide (38.1 mg) in DMSO (10 mL) was stirred under nitrogen atmosphere at 180° C. for 1 hr. The reaction mixture was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (28.5 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371320B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-570f7907048b47b0b99e76bb4701b7d8 |
| Source note | uspto-grants-2016_06 |