Sodium Iodide → 3-phenyl-1-(3-thienyl)-1,6-dihydro-7H-pyrazolo[3,4-c]pyridin-7-one

Participants

Reaction Conditions

Reaction Steps

To a solution of 7-methoxy-3-phenyl-1-(3-thienyl)-1H-pyrazolo[3,4-c]pyridine (28.5 mg) in acetonitrile (10 mL) were added sodium iodide (27.8 mg) and chloro(trimethyl)silane (81 mg), and the mixture was stirred at 60° C. for 1 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane), and crystallized from ethyl acetate and hexane to give the title compound (24.5 mg).

Provenance & Evidence