HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 117988542, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | HCID 117987921 | HCID 117987921 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 117988542 | HCID 117988542 | 31.3% |
Reaction Steps
A solution of 4-iodo-2-methoxy-N′-(tetrahydro-2H-pyran-3-yl)nicotinohydrazide (484 mg), L-proline (29.5 mg), potassium carbonate (355 mg) and copper(I) iodide (24.4 mg) in DMSO (25 mL) was stirred under nitrogen atmosphere at room temperature for 3 hr. The reaction mixture was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (100 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371320B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-d592916910c34fd9a3a018f645dfc68c |
| Source note | uspto-grants-2016_06 |