HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2206051Generated: November 3, 2026
Potassium Carbonate → HCID 117988108, compound
https://huagongshe.com/reaction/2206051
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | HCID 117987995 | HCID 117987995 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 117988108 | HCID 117988108 | 30.8% |
Reaction Steps
To a solution of N′-(2,6-difluorophenyl)-4-iodo-2-methoxynicotinohydrazide (1.32 g) in DMSO (20 mL) were added L-proline (75.0 mg) and potassium carbonate (901 mg) at room temperature. Copper(I) iodide (62.1 mg) was added thereto under nitrogen atmosphere at 60° C., and the mixture was stirred overnight at 60° C. The reaction mixture was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (278 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09371320B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-9e85f29697a34150b7f3dcd354ac00fb |
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| Source note | uspto-grants-2016_06 |
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