Water → HCID 117987736, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 4-(4-cyano-3-cyclopentyl-7-methoxy-1H-pyrazolo[3,4-c]pyridin-1-yl)thiophene-2-carboxylate (40 mg) in acetonitrile (5 mL) were added sodium iodide (31.4 mg) and chloro(trimethyl)silane (0.066 mL), and the mixture was stirred at 60° C. for 30 min. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogencarbonate solution and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the title compound (20 mg).

Provenance & Evidence