HuagongsheHuagongshe Chemistry Print Report · For research reference only
trans-2-Methylcyclopentan-1-ol → HCID 131735830, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | trans-2-Methylcyclopentan-1-ol | HCID 32804 | — |
| Reactant | Cyanomethylenetributylphosphorane | HCID 4622928 | — |
| Reactant | HCID 131735828 | HCID 131735828 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 131735830 | HCID 131735830 | 35% |
Reaction Steps
A solution of ethyl (2E)-3-(4-bromo-1H-pyrrol-2-yl)acrylate (1.3 g), trans-2-methylcyclopentanol (0.64 g) and 2-(tributylphosphoranylidene)acetonitrile (1.928 g) in toluene (12.6 mL) was stirred with heating under reflux for 22 hr under argon atmosphere. The reaction mixture was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (608 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371320B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-4eee57bcbf6c401ba5e0171104f571de |
| Source note | uspto-grants-2016_06 |