Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Reactant | 6-Fluoroisatoic anhydride | HCID 2783057 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 68715290 | HCID 68715290 | — |
Reaction Steps
6-Fluoro isatoic anhydride and 1,2-phenylenediamine were dissolved in acetic acid (80%) and the mixture heated at 115° C. for 2 hrs. The mixture was poured in water and extracted with ethyl acetate, washed with bicarbonate solution, dried and 2-fluoro-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-one was isolated (93%) by evaporation of solvent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08202989B2 |
|---|
| Source dataset | uspto-grants-2012_06 |
|---|
| ORD ID | ord-75a0d36f32844c9c9fd89dd83930d3a2 |
|---|
| Source note | uspto-grants-2012_06 |
|---|
