Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Reactant | 5-chloro-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione | HCID 639058 | — |
| Product | HCID 10657978 | HCID 10657978 | — |
Reaction Steps
6-Chloro isatoic anhydride (0.1 mol) and 1,2-phenylenediamine (0.1 mol) were dissolved in acetic acid (90%) and the mixture heated at 100° C. for 2.5 hrs. The mixture was poured into water and extracted with ethyl acetate, neutralized, dried and 2-chloro-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-one was isolated (94%) after removal of solvent under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08202989B2 |
|---|
| Source dataset | uspto-grants-2012_06 |
|---|
| ORD ID | ord-3711c68810ac4cc4a9ff768a19786eec |
|---|
| Source note | uspto-grants-2012_06 |
|---|
