HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 220610Generated: October 27, 2026
Isatoic Anhydride → 8,9-dimethyl-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-one
https://huagongshe.com/reaction/220610
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isatoic Anhydride | HCID 8359 | — |
| Reactant | 3,4-Dimethylbenzene-1,2-diamine | HCID 521077 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 8,9-dimethyl-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-one | HCID 50992452 | — |
Reaction Steps
3,4-Dimethyl-1,2-phenylenediamine (0.1 mol) was dissolved in acetic acid (70%) and then isatoic anhydride (0.1 mol) was added to the solution. The resulting mixture was heated at 85° C. for 3 hrs. The mixture was poured into ice-cold water and 8,9-dimethyl-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-one was isolated (97%) by neutralization and filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08202989B2 |
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| Source dataset | uspto-grants-2012_06 |
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| ORD ID | ord-ea109a5a82ea48d4ad4beb72793f8010 |
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| Source note | uspto-grants-2012_06 |
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