反应详情

温度

110 °C

A mixture of 4-methyl-1,2-phenylenediamine (0.1 mol) and 6-chloro isatoic anhydride (0.1 mol) in acetic acid (85%) was heated at 110° C. for 2 hrs. The mixture was poured into ice-cold water and 2-chloro-8-methyl-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-one was isolated (93%) after neutralisation and filtration.

1. additionThe mixture was poured into ice-cold water