HCID 131735836, compound → HCID 131735835, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(cyclopent-1-en-1-yl)-7-methoxy-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-c]pyridine-4-carbonitrile (690 mg) in methanol (5 mL) was added 10% palladium/carbon (100 mg). The reaction mixture was stirred overnight under hydrogen atmosphere (1 atm) at 50° C., and the insoluble substance was removed by filtration through Celite. The filtrate was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (519 mg).

Provenance & Evidence