Hydrogen chloride-ethyl acetate → HCID 117988376, compound

HRID 2206128Notes

Reaction equation

HRID 2206128 reaction equation
[CH:1]1([N:6]2[C:14]3[C:13]([C:15]#[N:16])=[CH:12][NH:11][C:10](=[O:17])[C:9]=3[C:8]([C:18]3[N:22](C4CCCCO4)[N:21]=[CH:20][CH:19]=3)=[CH:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:29].C(OCC)(=O)C>C(O)C>[ClH:29].[CH:1]1([N:6]2[C:14]3[C:13]([C:15]#[N:16])=[CH:12][NH:11][C:10](=[O:17])[C:9]=3[C:8]([C:18]3[NH:22][N:21]=[CH:20][CH:19]=3)=[CH:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 117988501HCID 117988501, compound

Product 1

HCID 117988376HCID 117988376, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1-cyclopentyl-4-oxo-3-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile and 4N hydrogen chloride/ethyl acetate solution (1.31 mL) in ethanol (2 mL) was stirred overnight at 50° C., and the solvent was evaporated under reduced pressure. The residue was crystallized from ethanol and diisopropyl ether to give the title compound (136 mg).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was crystallized from ethanol and diisopropyl ether

Sources & evidence

ORD record
ord-13836f339cb54f86b3eb85971af406fb
Source dataset
uspto-grants-2016_06
Patent number
US09371320B2

Reaction notes

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