HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2206169Generated: November 2, 2026
Sodium Iodide → 4-(7-cyano-1-cyclopentyl-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)thiophene-2-carboxamide
https://huagongshe.com/reaction/2206169
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 4-(7-cyano-1-cyclopentyl-4-methoxy-1H-pyrazolo[4,3-c]pyridin-3-yl)thiophene-2-carboxamide | HCID 117987715 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-(7-cyano-1-cyclopentyl-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)thiophene-2-carboxamide | HCID 137010697 | 98.1% |
Reaction Steps
To a solution of 4-(7-cyano-1-cyclopentyl-4-methoxy-1H-pyrazolo[4,3-c]pyridin-3-yl)thiophene-2-carboxamide (53.3 mg) in acetonitrile (10 mL) were added sodium iodide (43.5 mg) and chloro(trimethyl)silane (0.147 mL), and the mixture was stirred at 60° C. for 30 min. The reaction mixture was concentrated under reduced pressure, and the residue was washed successively with water and ethyl acetate to give the title compound (50.3 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09371320B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-2be2cd54110e4bd7aeecf9d09a8ba579 |
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| Source note | uspto-grants-2016_06 |
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