Hydrochloric Acid → HCID 59740540, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 90 mg (0.32 mmol) of 5-chloro-7-dimethylaminomethyl-1H-indole-2-carboxylic acid ethyl ester in THF/EtOH/H2O (5 ml) at RT was added 23 mg of LiOH.H2O. The reaction mixture was stirred at 45° C. for one hour and then acidified with aqueous HCl 1M. The product was extracted with EtOAc and concentrated under vacuo to afford 34 mg (42%) of 5-chloro-7-dimethylaminomethyl-1H-indole-2-carboxylic acid as a white solid. ES-MS m/e (%): 251.3 (M−H+).

Provenance & Evidence