HCID 12979375, compound → 933759-95-6

HRID 220623Notes

Reaction equation

HRID 220623 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([C:14]=1[CH3:15])=[CH:12][CH:11]=[CH:10][C:9]=2[CH3:16])=[O:5])C.ClC1C=C2C(=C(CC#N)C=1)NC(C(O)=O)=C2>>[CH3:15][C:14]1[C:13]2[C:8](=[C:9]([CH3:16])[CH:10]=[CH:11][CH:12]=2)[NH:7][C:6]=1[C:4]([OH:5])=[O:3]

Participants

3

Reactant 2

HCID 12979375HCID 12979375, compoundHCID 59740493HCID 59740493, compound2×

Product 1

HCID 22338158933759-95-6

Procedure

The title compound is prepared by saponification of 3,7-dimethyl-1H-indole-2-carboxylic acid ethyl ester (prepared by Fischer indole synthesis as described in Tetrahedron Lett. 2003, 44, 5665) using the procedure described above for the synthesis of 5-chloro-7-cyanomethyl-1H-indole-2-carboxylic acid (acid 1, step g)).

Sources & evidence

ORD record
ord-20076bc89b32487e8330772bdb1cc048
Source dataset
uspto-grants-2012_06
Patent number
US08202993B2

Reaction notes

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