Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Sodium Thiosulfate | HCID 24477 | — |
| Reactant | 4-chloro-1H-pyrazolo[4,3-c]pyridine | HCID 46835637 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 178478341 | HCID 178478341 | 86.5% |
Reaction Steps
To a mixture of 4-chloro-1H-pyrazolo[4,3-c]pyridine (4.0 g) and potassium hydroxide (4.4 g) in DME (50 mL) was added iodine (13.3 g) at room temperature. The reaction mixture was stirred at 75° C. for 4 hr. The reaction mixture was added to aqueous sodium thiosulfate solution, and the mixture was left stand overnight, and the resulting solid was collected by filtration to give the title compound (6.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09371320B2 |
|---|
| Source dataset | uspto-grants-2016_06 |
|---|
| ORD ID | ord-5e0d89dc4c6544d79511c505d2dcf26b |
|---|
| Source note | uspto-grants-2016_06 |
|---|
