HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium hydroxide, monohydrate → 1-(cyanomethyl)-1H-indole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | ethyl 1-(cyanomethyl)-1H-indole-2-carboxylate | HCID 713238 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | 1-(cyanomethyl)-1H-indole-2-carboxylic acid | HCID 6424793 | 70% |
Reaction Steps
To a solution of 1.0 eq. of 1-cyanomethyl-1H-indole-2-carboxylic acid ethyl ester in a mixture of THF/H2O ((9/1) was added LiOH.H2O (1.0 eq.) and the reaction mixture stirred 6 h at RT, acidified to pH2 and then partially concentrated until precipitation of the crude product which was filtered off and washed with Et2O and then dried to give the desired product as a light yellow solid (70%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202993B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-8c61ffdcc24f480b9c83cf8ac5f2d901 |
| Source note | uspto-grants-2012_06 |