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Formic Acid → tert-Butyl {(phenylsulphonyl)[3-(trifluoromethyl)phenyl]methyl}carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formic Acid | HCID 284 | — |
| 反応物 | 3-(Trifluoromethyl)benzaldehyde | HCID 67990 | — |
| 反応物 | tert-Butyl carbamate | HCID 77922 | — |
| 反応物 | Benzenesulfinic acid, sodium salt | HCID 2723840 | — |
| 溶媒 | Methanol--water (1/1) | HCID 22242641 | — |
| 生成物 | tert-Butyl {(phenylsulphonyl)[3-(trifluoromethyl)phenyl]methyl}carbamate | HCID 59536907 | — |
反応手順
A quantity of 4.49 g (38.29 mmol) of tert-butyl carbamate and 12.57 g (76.57 mmol) of sodium benzenesulphinate were introduced in 110 ml of methanol/water 1:2 and admixed in succession with 10 g (57.43 mmol) of 3-(trifluoromethyl)benzenecarbaldehyde and 2.87 ml (76.09 mmol) of formic acid. The mixture was stirred at RT for 30 h. The precipitated product was isolated by filtration, washed in succession with water and diethyl ether and sucked dry. Further drying in an HV gave 11.2 g (47% of theory) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08202895B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-dd01c49f80e34d9485cb26a159e4f399 |
| 出典メモ | uspto-grants-2012_06 |