Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Malononitrile | HCID 8010 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Sesamol | HCID 68289 | — |
| Reactant | 3-Bromo-5-methoxy-4-(2-propen-1-yloxy)benzaldehyde | HCID 2168163 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 3260543 | HCID 3260543 | — |
Reaction Steps
3,4-Methylenedioxyphenol (166 mg, 1.2 mmol), 4-allyloxy-3-bromo-5-methoxy-benzaldehyde (271 mg, 1 mmol) and malononitrile (66 mg, 1 mmol) were taken in 7 ml ethanol at room temperature, charged with piperidine (50 μL) and then stirred at 80° C. under LC-MS control till the reaction was complete. The reaction mixture was cooled down to room temperature, diluted with 10 ml water, stirred for 2 h at room temperature, solids were collected by filtration, washed with 1:1 mixture of ethanol/water and dried (200 mg, 0.44 mmol, 44%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09371333B2 |
|---|
| Source dataset | uspto-grants-2016_06 |
|---|
| ORD ID | ord-51cd70c852f74467ab2482d14ea55c12 |
|---|
| Source note | uspto-grants-2016_06 |
|---|
