Acetic Anhydride → HCID 69084049, compound

HRID 2206309Notes

Reaction equation

HRID 2206309 reaction equation
[NH2:1][C:2]1[O:3][C:4]2[C:9]([CH:10]([C:14]3[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([Br:24])[CH:15]=3)[C:11]=1[C:12]#[N:13])=[CH:8][CH:7]=[C:6]1[C:25]([NH2:29])=[CH:26][CH:27]=[CH:28][C:5]=21.[C:30](OC(=O)C)(=[O:32])[CH3:31]>N1C=CC=CC=1.O>[NH2:1][C:2]1[O:3][C:4]2[C:9]([CH:10]([C:14]3[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([Br:24])[CH:15]=3)[C:11]=1[C:12]#[N:13])=[CH:8][CH:7]=[C:6]1[C:25]([NH:29][C:30](=[O:32])[CH3:31])=[CH:26][CH:27]=[CH:28][C:5]=21

Participants

5

Reactant 2

HCID 7918Acetic AnhydrideHCID 69083139HCID 69083139, compound

Product 1

HCID 69084049HCID 69084049, compoundYield 93.1%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1049PyridineSolvent

Conditions

Temperature
0 °C

Procedure

2,7-Diamino-4-(3-bromo-4,5-dimethoxy-phenyl)-4H-benzo[h]chromene-3-carbonitrile (10) (45 mg, 0.1 mmol) was taken in pyridine (2 ml) at 0° C., charged with acetic anhydride (11 mg, 0.11 mmol) and stirred further at 0° C. under LC-MS control. The reaction mixture was diluted with water (10 ml) under stirring, stirred further at room temperature for 2 h, the precipitates were collected by filtration, washed with water and dried to get the title compound (46 mg, 93%).

Workup

  1. stirringunder stirring
  2. stirringstirred further at room temperature for 2 h
  3. filtrationthe precipitates were collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-24af19f90c8f460ca5de37a2587c781a
Source dataset
uspto-grants-2016_06
Patent number
US09371333B2

Reaction notes

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