Hydrochloric Acid → N-{2-Amino-2-[3-(trifluoromethyl)phenyl]ethyl}formamide hydrochloride

HRID 220636ノート

反応式

HRID 220636 の反応式
[CH:1]([NH:3][CH2:4][CH:5]([NH:16]C(=O)OC(C)(C)C)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1)=[O:2].[ClH:24]>ClCCl.O1CCOCC1>[ClH:24].[NH2:16][CH:5]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:13])([F:14])[F:15])[CH:7]=1)[CH2:4][NH:3][CH:1]=[O:2]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 59536815tert-Butyl {2-(formylamino)-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

生成物 1

HCID 86646631N-{2-Amino-2-[3-(trifluoromethyl)phenyl]ethyl}formamide hydrochloride

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

Of the compound from Example 23A, 66 mg (0.2 mmol) were introduced in 1.5 ml of dichloromethane and admixed at RT with 1.56 ml of a 4N solution of hydrogen chloride in dioxane. The reaction mixture was stirred at RT for 1 h. The reaction mixture was freed from the volatile components on a rotary evaporator and dried in an HV. This gave 50 mg (94% of theory) of the title compound.

後処理

  1. customThe reaction mixture was freed from the volatile components on a rotary evaporator
  2. customdried in an HV

出典と根拠

ORDレコード
ord-a394ffb702414dcea71ab773ff0d5ee8
出典データセット
uspto-grants-2012_06
特許番号
US08202895B2

反応ノート

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