HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxy-5-(5-methyl-1h-tetrazol-1-yl)aniline → 3-((3-Cyano-6-((3-methoxy-5-(5-methyl-1H-tetrazol-1-yl)phenyl)amino)imidazo[1,2-b]pyridazin-8-yl)amino)-N-(2-(dimethylamino)ethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxy-5-(5-methyl-1h-tetrazol-1-yl)aniline | HCID 3155252 | — |
| Reactant | 3-((6-Chloro-3-cyanoimidazo[1,2-b]pyridazin-8-yl)(4-methoxybenzyl)amino)-N-(2-(dimethylamino)ethyl)benzamide | HCID 59313763 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-((3-Cyano-6-((3-methoxy-5-(5-methyl-1H-tetrazol-1-yl)phenyl)amino)imidazo[1,2-b]pyridazin-8-yl)amino)-N-(2-(dimethylamino)ethyl)benzamide | HCID 59313841 | — |
Reaction Steps
Example 255 was prepared from 253D and 3-methoxy-5-(5-methyl-1H-tetrazol-1-yl)aniline following the procedure as described in Example 6. HPLC: Rt=3.11 min. (YMC S5 ODS 4.6×50 mm, 10-90% aqueous methanol containing 0.2% H3PO4, 4 min. gradient, monitored at 220 nm). MS (ES): m/z=512.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371328B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-849503546fc245dc807461abbde84e3c |
| Source note | uspto-grants-2016_06 |