Trifluoroacetic acid → HCID 86704074, compound

Participants

Reaction Steps

In a manner similar to the method described in Example 4, chiral 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid 2-((R)-2-tert-butoxycarbonylamino-propionyloxy)-ethyl ester (Example 5, 112 mg, 0.135 mmol) in methylene chloride (2 mL) was treated with trifluoroacetic acid (2 mL) to give chiral 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid 2-((R)-2-amino-propionyloxy)-ethyl ester as a white solid. MS (ES+) m/z calcd. for C36H39Cl2F2N4O6 [(M+H)+]: 731. found: 731.

Provenance & Evidence