1-Methyl-4-piperidinemethanol → HCID 72549330, compound

Participants

Reaction Steps

In a manner similar to the method described in Example 14, 4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid (prepared as described in US20100152190A1) was reacted with (1-methylpiperidin-4-yl)methanol to give 4-{[(2R,3S,4R,5S)-4-(4-chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid 1-methyl-piperidin-4-ylmethyl ester. MS (ES+) m/z calcd. for C38H43Cl2F2N4O4: [(M+H)+]: 727. found: 727.

Provenance & Evidence