N,N-Diethylethylenediamine → HCID 86704076, compound

Participants

Reaction Steps

In a manner similar to the method described in Example 14, 4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid (prepared as described in US20100152190A1) was reacted with N,N-diethylethane-1,2-diamine to give (2R,3S,4R,5S)-4-(4-chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carboxylic acid [4-(2-diethylamino-ethylcarbamoyl)-2-methoxy-phenyl]-amide hydrochloride. MS (ES+) m/z calcd. for C37H44Cl2F2N5O3: [(M+H)+]: 714. found: 714.

Provenance & Evidence