2-Hydroxy-N,N-dimethylacetamide → HCID 131735858, compound

Participants

Reaction Steps

In a manner similar to the method described in Example 14, 4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid (prepared as described in US20100152190A1) was reacted with 2-hydroxy-N,N-dimethylacetamide to give 4-{[(2R,3S,4R,5S)-4-(4-chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid dimethylcarbamoylmethyl ester, hydrochloride. MS (ES+) m/z calcd. for C35H37Cl2F2N4O5: [(M+H)+]: 703. found: 703.

Provenance & Evidence