Sorbitol → HCID 72550016, compound

Participants

Reaction Steps

In a manner similar to the method described in Example 14, 4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid (prepared as described in US20100152190A1) was reacted with (2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexaol to give 4-{[(2R,3S,4R,5S)-4-(4-chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid (2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy-hexyl ester. MS (ES+) m/z calcd. for C37H42Cl2F2N3O9: [(M+H)+]: 780. found: 780.

Provenance & Evidence