Trifluoroacetic acid → HCID 131735861, compound

Participants

Reaction Steps

4-{[(2R,3S,4R,5S)-4-(4-chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid 2-[2-(tert-butoxycarbonyl-methyl-amino)-acetoxy]-ethyl ester (Example 31) was treated with trifluoroacetic acid to give 4-{[(2R,3S,4R,5S)-4-(4-chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid 2-(2-methylamino-acetoxy)-ethyl ester, hydrochloride. MS (ES+) m/z calcd. for C36H39Cl2F2N4O6: [(M+H)+]: 731. found: 731.

Provenance & Evidence