HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2206504Generated: October 30, 2026
Sodium Hydroxide → 1-Benzyl-2-methyl-1H-indole-3-carboxylic acid
https://huagongshe.com/reaction/2206504
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | methyl 1-benzyl-2-methyl-1H-indole-3-carboxylate | HCID 102362635 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Benzyl-2-methyl-1H-indole-3-carboxylic acid | HCID 66743481 | 50% |
Reaction Steps
To a solution of methyl 1-benzyl-2-methyl-1H-indole-3-carboxylate (446 mg, 1.6 mmol) in tetrahydrofuran (20 mL) and methanol (7 mL) was added sodium hydroxide (320 mg, 8 mmol) in water (7 mL), then stirred at 60° C. for 12 hours. The reaction mixture was concentrated in vacuo and acidified to PH=4 with 6 N hydrochloric acid, collected and dried to give 1-benzyl-2-methyl-1H-indole-3-carboxylic acid as a white solid (212 mg, 50%). LRMS (M+H+) m/z: calcd 265.11. found 265.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09371331B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-b04824d2d5d14de2ab6f0ba3289f2fb5 |
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| Source note | uspto-grants-2016_06 |
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