D-Psicose → HCID 117779006, compound

Participants

Reaction Steps

Methyl 3-(1-(3-(((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methy)carbamoyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl)benzoate (20 mg, 0.041 mmol) was added to 30% methylamine ethanol solution (10 mL). The mixture was stirred under 50 Psi at 100° C. for 12 hours in a 100 mL of sealed tube. The solvent was evaporated and the residue was purified by preparative-HPLC (Instrument: Gilson GX281 Column: ASB C18 150*25 mm*5 um Mobile phase A: water with 0.05% ammonia solution Mobile phase B: MeCN Column temperature: 30° C. Gradient: 17-47% B 15 min) to afford the title compound (17.4 mg, yield: 30%). LRMS (M+H+) m/z: calcd 488.22. found 488.0. 1H NMR (400 MHz, chloroform-d) δ ppm 2.01 (d. J=7.28 Hz, 3H) 2.26 (s, 3H) 2.50 (s, 3H) 2.96 (d, J=4.63 Hz, 3H) 3.91 (s, 3H) 4.64 (d, J=5.51 Hz, 2H) 5.95 (s, 1H) 6.14 (br. S., 1H) 6.55 (d, J=8.16 Hz, 1H) 7.05-7.13 (m, 1H) 7.33 (t, J=8.05 Hz, 1H) 7.51-7.59 (m, 1H) 7.60-7.64 (m, 1H) 8.24 (d, J=5.51 Hz, 2H).

Provenance & Evidence