HCID 117779104, compound → HCID 117778972, compound

HRID 2206581Notes

Reaction equation

HRID 2206581 reaction equation
[OH:1][CH2:2][CH:3]([N:5]1[C:9]2=[N:10][CH:11]=[CH:12][CH:13]=[C:8]2[C:7]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])=[C:6]1[CH3:21])[CH3:4]>C(Cl)Cl>[CH3:21][C:6]1[N:5]([CH:3]([CH3:4])[CH:2]=[O:1])[C:9]2=[N:10][CH:11]=[CH:12][CH:13]=[C:8]2[C:7]=1[C:14]([O:16][C:17]([CH3:18])([CH3:20])[CH3:19])=[O:15]

Participants

3

Reactant 1

HCID 117779104HCID 117779104, compound

Product 1

HCID 117778972HCID 117778972, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To tert-butyl 1-(1-hydroxypropan-2-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (380 mg, 1.31 mmol) in CH2Cl2 (5 ml) were added DMP (610.6 mg, 1.44 mmol) at 25° C. for 18 h. After the reaction completed, the solution was purified by silica gel and concentrated under reduced pressure to give tert-butyl 2-methyl-1-(1-oxopropan-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate as a white oil (200 mg, yield 53%).

Workup

  1. customthe solution was purified by silica gel
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-137aecd0a1964d12a45158c22e731c90
Source dataset
uspto-grants-2016_06
Patent number
US09371331B2

Reaction notes

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