HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2206589Generated: October 30, 2026
tert-Butyl piperazine-1-carboxylate → Tert-butyl 4-(6-aminopyridin-2-yl)piperazine-1-carboxylate
https://huagongshe.com/reaction/2206589
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 2-Amino-6-chloropyridine | HCID 206246 | — |
| Product | Tert-butyl 4-(6-aminopyridin-2-yl)piperazine-1-carboxylate | HCID 50986448 | 28% |
Reaction Steps
A mixture of 6-chloropyridin-2-amine (10 g, 78 mmol) and tert-butyl piperazine-1-carboxylate (29 g, 156 mmol) was refluxed at 140° C. for 3 days. The reaction mixture was purified by silica gel column chromatography (elute: petroleum ether/ethyl acetate=2:1) to give tert-butyl 4-(6-aminopyridin-2-yl)piperazine-1-carboxylate (6 g, 28%). LCMS (M+H) m/z: calcd 278.17. found 279.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09371331B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-89447d4b2bfa459f91651848991c6e8a |
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| Source note | uspto-grants-2016_06 |
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