Methanesulfonyl chloride → HCID 59536886, compound

HRID 220660Notes

Reaction equation

HRID 220660 reaction equation
[NH2:1][CH2:2][CH:3]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[Cl:10].[CH3:19][S:20](Cl)(=[O:22])=[O:21]>N1C=CC=CC=1>[Cl:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[CH:3]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:15])([CH3:17])[CH3:16])[CH2:2][NH:1][S:20]([CH3:19])(=[O:22])=[O:21]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 59536931HCID 59536931, compound

Product 1

HCID 59536886HCID 59536886, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 330 mg (1.15 mmol) of the compound from Example 113A in 7 ml of pyridine was admixed at RT with 177 μl (2.29 mmol) of methanesulphonyl chloride. After 1 h the volatile constituents were removed on a rotary evaporator. The residue is purified by preparative HPLC [Method 23]. The product fraction was freed from the solvents on a rotary evaporator. Drying of the residue in an HV gave 312 mg (78% of theory) of the title compound.

Workup

  1. customAfter 1 h the volatile constituents were removed on a rotary evaporator
  2. customThe residue is purified by preparative HPLC [Method 23]
  3. customThe product fraction was freed from the solvents on a rotary evaporator
  4. customDrying of the residue in an HV

Sources & evidence

ORD record
ord-61493ef66daa4494aec65301c21fef48
Source dataset
uspto-grants-2012_06
Patent number
US08202895B2

Reaction notes

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