HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanoacetamide → 3-Cyano-4,6-dimethyl-2-hydroxypyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Acetylacetone | HCID 31261 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Cyano-4,6-dimethyl-2-hydroxypyridine | HCID 69856 | 93.1% |
Reaction Steps
To a solution of pentane-2,4-dione (100 g, 1.0 mol) in H2O (2 L) were added 2-cyanoacetamide (84 g, 1.0 mol) and K2CO3 (13.8 g, 0.1 mol). Then the mixture was stirred at room temperature for 16 hr. The reaction solution was filtrated to give crude product. The crude was washed with water and concentrated to give 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (138 g, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371331B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-7f50d06cd7374b89b5483de774352923 |
| Source note | uspto-grants-2016_06 |