Ethyl chloroformate → HCID 59536793, compound

HRID 220664Notes

Reaction equation

HRID 220664 reaction equation
[NH2:1][CH2:2][CH:3]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:5]=1[Cl:11].Cl[C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[Cl:11][C:5]1[C:6]([Cl:10])=[CH:7][CH:8]=[CH:9][C:4]=1[CH:3]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:16])([CH3:18])[CH3:17])[CH2:2][NH:1][C:21](=[O:22])[O:23][CH2:24][CH3:25]

Participants

3

Reactant 2

HCID 10928Ethyl chloroformateHCID 59536725HCID 59536725, compound

Product 1

HCID 59536793HCID 59536793, compound

Procedure

From 192 mg (629 μmol) of the compound from Example 40A and 72 μl (755 μmol) of ethyl chloroformate, in the same way as for Example 123A, 184 mg (78% of theory) of the title compound were prepared.

Sources & evidence

ORD record
ord-4b3eef4cfb384aafbeb349bd2a97306e
Source dataset
uspto-grants-2012_06
Patent number
US08202895B2

Reaction notes

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