HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1-Morpholin-2-YL-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 2-acetylmorpholine-4-carboxylate | HCID 70990574 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Morpholin-2-YL-ethanone | HCID 22263552 | 100.7% |
Reaction Steps
To a solution of tert-butyl 2-acetylmorpholine-4-carboxylate (6.9 g, 30.0 mmol) in DCM (80 mL) was added TFA (20 mL). The mixture was stirred at room temperature for 4 hr. The reaction mixture was concentrated to give 1-(morpholin-2-yl)ethanone (3.9 g, crude) for next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371331B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-f833a038cd7245faa652a8cace4c24b9 |
| Source note | uspto-grants-2016_06 |