HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → Methyl 2-amino-3-methoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Benzoic acid, 3-methoxy-2-nitro-, methyl ester | HCID 79195 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 2-amino-3-methoxybenzoate | HCID 602320 | 99.7% |
Reaction Steps
A suspension of compound 52 (26.2 g, 124 mmol) and Pd/C (10 wt. %, 6.0 g) in THF (400 mL) and MeOH (200 mL) was stirred under an atmosphere of H2 at room temperature for 18 hours. EtOAc (300 mL) was added to the mixture and filtered through a Celite pad. The filtrate was concentrated in vacuo to provide the crude product 53 (22.4 g, 99%) as colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371303B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-f29ead4b9b4b443baed769dc2288e81c |
| Source note | uspto-grants-2016_06 |