Acetic Acid → HCID 71076877, compound

HRID 2206715Notes

Reaction equation

HRID 2206715 reaction equation
C([O:4][C@@H:5]1[C@@H:10]([O:11]C(=O)C)[C@H:9]([OH:15])[C@@H:8]([CH2:16][O:17]C(=O)C)[O:7][C@H:6]1[C:21]1[CH:26]=[C:25]([O:27][CH3:28])[C:24]([Cl:29])=[C:23]([CH2:30][C:31]2[CH:36]=[CH:35][C:34]([O:37][CH2:38][CH3:39])=[CH:33][CH:32]=2)[CH:22]=1)(=O)C.C[O-].[Na+].CC(O)=O>CO>[Cl:29][C:24]1[C:25]([O:27][CH3:28])=[CH:26][C:21]([C@H:6]2[C@H:5]([OH:4])[C@@H:10]([OH:11])[C@H:9]([OH:15])[C@@H:8]([CH2:16][OH:17])[O:7]2)=[CH:22][C:23]=1[CH2:30][C:31]1[CH:36]=[CH:35][C:34]([O:37][CH2:38][CH3:39])=[CH:33][CH:32]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 10942334Sodium MethoxideHCID 86714051HCID 86714051, compound

Product 1

HCID 71076877HCID 71076877, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of acetate 74-5 (2.5 g, 4.12 mmol) in MeOH (40 mL) was added NaOMe (25 wt % in MeOH, 0.75 mL) at room temperature. The mixture was stirred at room temperature for 1 hour. Glacial AcOH was added to the mixture to acidify the mixture. The mixture was concentrated under reduced pressure. The residue was carried on to the next step without purification.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customThe residue was carried on to the next step without purification

Sources & evidence

ORD record
ord-2eb558d049f34ed8839267f0d0d9451b
Source dataset
uspto-grants-2016_06
Patent number
US09371303B2

Reaction notes

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