Sodium Hydroxide → HCID 71076950, compound

HRID 2206730Notes

Reaction equation

HRID 2206730 reaction equation
[Br:1][C:2]1[C:7]2[S:8][CH:9]=[CH:10][C:6]=2[C:5]([Cl:11])=[C:4]([C:12]([O:14]C)=[O:13])[CH:3]=1.[OH-].[Na+]>CCO>[Br:1][C:2]1[C:7]2[S:8][CH:9]=[CH:10][C:6]=2[C:5]([Cl:11])=[C:4]([C:12]([OH:14])=[O:13])[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 71076844HCID 71076844, compound

Product 1

HCID 71076950HCID 71076950, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of methyl 7-bromo-4-chlorobenzo[b]thiophene-5-carboxylate 96 (1.06 g, 3.3 mmol) in aqueous EtOH (40 mL) was added NaOH (400 mg, 10 mmol). The reaction mixture was stirred for 3 hours at room temperature. After the reaction was completed, the volatile solvent was removed under reduced pressure, acidification with 1 N HCl was accomplished. Drying with MgSO4 was followed by normal work-up with EtOAc. After evaporating volatile solvent, the residue was used without further purification in ˜88% yield.

Workup

  1. customthe volatile solvent was removed under reduced pressure, acidification with 1 N HCl
  2. dry with materialDrying with MgSO4
  3. customAfter evaporating volatile solvent
  4. customthe residue was used without further purification in ˜88% yield

Sources & evidence

ORD record
ord-39761854ea8b43b0b024bd36efc4fbba
Source dataset
uspto-grants-2016_06
Patent number
US09371303B2

Reaction notes

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