反应详情

To a solution of methyl 7-bromo-4-chlorobenzo[b]thiophene-5-carboxylate 96 (1.06 g, 3.3 mmol) in aqueous EtOH (40 mL) was added NaOH (400 mg, 10 mmol). The reaction mixture was stirred for 3 hours at room temperature. After the reaction was completed, the volatile solvent was removed under reduced pressure, acidification with 1 N HCl was accomplished. Drying with MgSO4 was followed by normal work-up with EtOAc. After evaporating volatile solvent, the residue was used without further purification in ˜88% yield.

1. customthe volatile solvent was removed under reduced pressure, acidification with 1 N HCl
2. dry with materialDrying with MgSO4
3. customAfter evaporating volatile solvent
4. customthe residue was used without further purification in ˜88% yield