反应详情

To a solution of tert-butyl {6-[({[(Z)-cyano(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate (5.4 g, 15.32 mmol, 1 eq.) in DCM (200 ml) was added TFA (17.47 g, 153 mmol, 10 eq.). The solution was refluxed for 12 h. The reaction was quenched by addition of aq. sat. NaHCO3 and extracted with EtOAc (3×50 ml). The organics were combined, dried over MgSO4 and concentrated to give (2Z)-{[(6-aminopyridin-2-yl)methoxy]imino}(phenyl)acetonitrile (3.86g, 89% yield).

1. temperatureThe solution was refluxed for 12 h
2. customThe reaction was quenched by addition of aq. sat. NaHCO3
3. extractionextracted with EtOAc (3×50 ml)
4. dry with materialdried over MgSO4
5. concentrationconcentrated