Lithium Chloride → HCID 59536731, compound

Participants

Reaction Conditions

Reaction Steps

Of the compound from Example 171A, 1.34 g (4.33 mmol) were dissolved in 10 ml of dimethoxyethane and admixed with 246 mg (6.50 mmol) of sodium borohydride and 37 mg (0.87 mmol) of lithium chloride. The mixture was heated at 85° C. for 16 h. For work-up, it was cooled to RT and cautiously admixed with 10 ml of saturated aqueous sodium potassium tartrate solution. It was extracted with three times 20 ml of ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtered and freed from the solvent on a rotary evaporator. The crude product was purified by chromatography on silica gel (elution: cyclohexane/ethyl acetate 9:1, 7:3). This gave 348 mg (29% of theory) of the title compound.

Provenance & Evidence