HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2206868Generated: October 27, 2026
Oxalyl chloride → 5-Fluoro-2-(trifluoromethyl)benzoyl chloride
https://huagongshe.com/reaction/2206868
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 5-Fluoro-2-(trifluoromethyl)benzoic acid | HCID 688294 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Fluoro-2-(trifluoromethyl)benzoyl chloride | HCID 2737560 | — |
Reaction Steps
Oxalyl chloride (1.23 ml, 14.24 mmol) was added dropwise to a solution of 5-fluoro 2-trifluoromethyl benzoic acid (1 gm, 4.81 mmol) in HPLC grade DCM (15 ml), containing DMAP. The reaction mixture was heated to 50° C. for 40 min. The reaction mass was cooled to room temperature and solvent evaporated to dryness under a nitrogen atmosphere to get crude 5-fluoro 2-trifluoromethyl benzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09375012B2 |
|---|
| Source dataset | uspto-grants-2016_06 |
|---|
| ORD ID | ord-d879dd37dc5d4c5095d0ac8f7df8af9b |
|---|
| Source note | uspto-grants-2016_06 |
|---|
